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KMID : 1145520170030010018
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Journal of Radiopharmaceuticals and Molecular Probes
2017 Volume.3 No. 1 p.18 ~ p.24
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Evaluation of absorbed dose in monkey and mouse using 18F-FDG PET and CT density information
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Kim Wook
Lee Yong-Jin
Park Yong-Sung
Cho Doo-Wan
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Abstract
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Patient-specific image-based internal dosimetry involves using the patient's individual anatomy and spatial distribution of radioactivity over time to obtain an absorbed dose calculation. Individual absorbed dose was calculated by accumulated activity multiply S-value of each organs. The aim of this study was to calculate the S-values using Monte Carlo simulation in monkey and mouse and evaluation of absorbed dose in each organ. Self-irradiation S-value of monkey heart self-irradiation was 3.15E-03 mGy-g/MBq-s, lung self-irradiation was 8.94E-04 mGy-g/MBq-s and liver self-irradiation S-value was 2.23E-03 mGy-g/MBq-s. Mouse heart self-irradiation S-value was 1.95E-01 mGy-g/MBq-s, lung was 9.59E-02 mGy-g/MBq-s, and liver was 1.40E-03 mGy-g/MBq-s. The results of this study show that the calculation protocol of image based individual absorbed dose of each organ using Monte Carlo simulation. Therefore, this study may be applied to calculate human specific absorbed dose.
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KEYWORD
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mage--based internal dosimetry , Monte Carlo simulation , S-value , Monkey
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